The avMpNp database (Antiviral Medicinal Plants and Natural Products) is a structured collection of information on chemically diverse compounds with antiviral activity, derived from medicinal plants and natural products. It was developed with the aim of centralizing and making available relevant knowledge related to antiviral drug discovery. The avMpNp database gathers information on bioactive compounds with therapeutic potential, isolated from medicinal plants and other natural resources, which have been investigated for their activity against viruses.